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Vivendy to present significant new preclinical data on its treatment for Morbus Morquio (MPS IVA)


Basel, Switzerland, Nov. 17, 2008 – Vivendy Therapeutics Ltd., intent on developing an enzyme replacement therapy (ERT) for Mucopolysaccharidosis IVA, (MPS IVA-Morbus Morquio), today announced that it will be presenting significant new pre-clinical data at the First Asia Pacific Lysosomal Diseases Conference in Christchurch, New Zealand, 20 – 23 November, 2008. New data will be presented concerning the pharmacokinetics, biodistribution and pharmacodynamics of the Company’s modified enzyme from experiments conducted using its proprietary Morquio mouse models.

These data are the result of a series of experiments that were conducted using the Company’s proprietary mouse models of Morquio disease. These models, that approximate the clinical condition in patients, allow the Company to gain insight into potential therapeutic features of its modified enzyme treatment and may serve to justify future clinical development activities with the regulatory authorities.

Dr. Shunji Tomatsu Ph.D., originator of Vivendy’s modified enzyme, will present: “ERT in Morquio A; from Basic Science to Clinical Application' on Friday, November 21st at 16:00 and Dr. Roland Toder, Ph.D. previously CEO of Vivendy and now its Asia Pacific representative will present: “ERT in Morquio A; Getting to the Target Tissues” on Saturday November 22nd at 13:30.

About Vivendy’s Enzyme Replacement Therapy (ERT)

Vivendy’s seeks to replace the lack of or deficient activity of the N-acetylgalactosamine-6- sulfatase (GALNS) enzyme in MPS IVA by administering a recombinant human GALNS enzyme that has been specifically modified – potentially enhancing the efficacy of the therapy in MPS IVA significantly. Compared to the native enzyme, Vivendy believes that the modification has the potential to maximize the delivery of the enzyme to efficiently clear the storage materials in target tissues and organs.


About Mucopolysaccharidosis (MPS) IVA:

Mucopolysaccharidosis (MPS) IVA (MPS IVA, also known as Morbus Morquio A) is a rare lysosomal storage disease characterized by a gene mutation that causes a lack or deficient activity of the N-acetylgalactosamine-6- sulfatase (GALNS) enzyme. This in turn causes excessive lysosomal storage of keratin sulfate (KS) and Chondroitin-6-Sulfate (C6S) which leads to multiple systemic skeletal, spine and joint abnormalities as well as malformations of the chest. Additionally, patients may suffer hearing loss, vision impairment, and heart valve disease. Accurate epidemiological data regarding the rate of incidence of MPS IVA is only sporadically available, but estimates vary between 1 in 250,000 live births to 1 in 500,000 live births.

About Vivendy Therapeutics Ltd.

Vivendy Therapeutics Ltd., a pharmaceutical company developing an enzyme replacement therapy (ERT) for Mucopolysaccharidosis (MPS) IVA (Morbus Morquio) was founded in March 2006, as a spin-off of Inotech Biotechnologies AG. The company's mission is the development of an enzyme replacement therapy (ERT) for Morbus Morquio. In June, 2008, Saint Louis University (SLU), Office of Innovation and Intellectual Property, St. Louis, Missouri, USA and Vivendy Therapeutics Ltd., finalized and signed a License Agreement where SLU granted to Vivendy Therapeutics the exclusive license to use its patents for the research, development, manufacturing, marketing, sales and other use of the licensed products in the field of Enzyme Replacement Therapy (ERT) compositions intended for the treatment of patients having MPS IVA (Morbus Morquio).

Contact address:

Gosse B. Bruinsma MD
Executive Director
Vivendy Therapeutics Ltd.
Peter Merian Str. 45
CH-4052 Basel
Switzerland
T: +41 61 271 8780
E: bruinsma@vivendy.ch
www.vivendy.ch

Media enquiries:

Dr. Robert Mayer
Account Manager
College Hill Life Sciences
T: +49 89 5238 8030
E: robert.mayer@collegehill.com


Publisher Contact Information:

Vivendy Therapeutics
+41 61 271 8780
bruinsma@vivendy.ch

Company profile of Vivendy Therapeutics
Past press releases of Vivendy Therapeutics.

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