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High-Tech Gründerfonds and Business Angel Invest in AudioCure Pharma GmbH Drug Development

BONN / BERLIN - 29.05.2012

AudioCure Pharma concentrates on the clinical development of drug candidates in neurodegenerative disease indications with a high unmet medical need. The lead candidate is a small molecule compound for the treatment of acute and chronic hearing impairments via local, regenerative therapy of the damaged nerve cells in the inner ear.

Seed financing from High-Tech Gründerfonds and business angel Dr. Schumacher will enable AudioCure to develop the lead compound for the medicinal treatment of hearing impairments in the preclinical phase. The first part of solving the problem targets the ototoxic side effects of cytostatics. The second field of application addresses the hearing impairments of acoustic trauma, tinnitus and acute hearing loss, later indications target hearing loss due to advancing age.

As a consequence of increasing life expectancy, the prevalence of neurodegenerative disorders is rising significantly worldwide. This is because genetic causes are only significant 5-10% of the time, while age plays the key role in a far larger number of cases. Thus, approx. 1% of people over the age of 65 and approx. 5% of those over 85 are affected by Parkinson’s disease. Worldwide, 580 million people suffer from moderate to severe hearing impairment – with an upwards trend. Medications currently applied for these indications do not show sufficient efficacy; hearing aids and surgical intervention are inadequate and costly.

Apart from the specific causes, there are many shared mechanisms in the pathogenesis of different neurodegenerative disorders. These include, for example, inflammatory processes, damaging oxygen-based free radicals, disrupted functioning of mitochondria and programmed cell death (apoptosis). AudioCure Pharma develops substances that significantly influence these processes. Additionally, the formation of a whole series of neurotrophins (nerve growth factors) activate the natural repair mechanisms.

Professor Rommelspacher explains, “Our approach envisions placing the compound locally in the middle ear, close to the area of the disorder. We were able to demonstrate that from there it enters the inner ear and acts to reduce inflammation, and to protect and regenerate cells. The efficacy spectrum is unique. Based on our current understanding of the pathological process a therapeutic effect on the sensory and nerve cells in the inner ear is anticipated. Among these, impairments to mitochondrial function, inflammatory processes and programmed cell death are being discussed as decisive pathological processes.”

“To date AudioCure’s results can for the first time enable a possible protective and regenerative effect on damaged nerve cells in the human inner ear – which is exactly what makes AudioCure appealing for early cooperation with pharmaceutical companies,” said Dr. Martin Pfister, Investment Manager at High-Tech Gründerfonds.

“The factors that tipped the scale for my early involvement in AudioCure were the combination of patent situation, the founding team and the lack of effective therapies in this field. Against the background of future exploitation, the innovative approach in combination with the large number of patients with various types of hearing impairments make this investment so interesting to me,” said Dr. Schumacher.

About AudioCure Pharma GmbH
The company was founded as a German limited liability company (GmbH) by university professor and doctor of medicine Hans Rommelspacher in Berlin on 13

th August 2010. In recent years he was the Head of Clinical Neurobiology at the Psychiatric Clinic of the Charité university hospital. He worked for over 20 years there on the effects of the primary compound used here. In the past few years extensive structure-activity experiments have been able to prove the neuroprotective and neuroregenerative, or therapeutic, potential of some derivatives in established animal models of Parkinson’s disease and in cell cultures.

Along with NanoPet Pharma Berlin and Wildau Technical University of Applied Sciences, AudioCure Pharma founded the NeuroPro Alliance research network. It is partially financed by the German Federal Ministry of Education and Research.

AudioCure Pharma GmbH
Dr. Hans Rommelspacher
Managing Director
Salzbrunner Str. 42
14913 Berlin Germany
Phone: +49 30 27594394
Fax: +49 30 27594491

About High-Tech Gruenderfonds
High-Tech Gruenderfonds invests in young, high potential high-tech start-ups. The seed financing provided is designed to enable start-ups to take an idea through prototyping and to market launch. Typically, High-Tech Gruenderfonds invests EUR 500,000 in the seed stage, with the potential for up to a total of EUR 2 million per portfolio company in follow-on financing. Investors in this public/private partnership include the Federal Ministry of Economics and Technology, the KfW Banking Group, as well as thirteen industrial groups of ALTANA, BASF, B. Braun, Robert Bosch, CEWE Color, Daimler, Deutsche Post DHL, Deutsche Telekom, Evonik, Qiagen, RWE Innogy, Tengelmann and Carl Zeiss. High-Tech Gruenderfonds has about EUR 563 million under management in two funds (EUR 272 million HTGF I, EUR 291 million HTGF II).

High-Tech Gründerfonds Management GmbH
Dr. Martin Pfister
Ludwig-Erhard-Allee 2,
53175 Bonn
Tel: +49 228 823001-00
Fax: +49 228 823000-50

Publisher Contact Information:

High-Tech Gründerfonds Management GmbH
+49 228 823001-00

Company profile of High-Tech Gründerfonds Management
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