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XOMA and Affimed Sign Antibody Cross-License and Collaboration Agreement

Berkeley, CA and Heidelberg, Germany - October 2, 2006 - XOMA Ltd. (Nasdaq: XOMA) and Affimed Therapeutics AG announced today that they have signed a cross-license and collaboration agreement for antibody-related technologies. Financial terms were not disclosed.

The agreement provides XOMA with a license under Affimed's antibody library patents for antibody discovery purposes, as well as for the development and commercialization of antibodies. In addition, Affimed has agreed to build two customized patient-derived human antibody phage display libraries according to XOMA specifications.

The agreement provides Affimed with a license to use XOMA's Bacterial Cell Expression (BCE) technology for research purposes, with an option to acquire a BCE license for production and commercialization of antibodies, in particular for Affimed's proprietary TandAb and Flexibody technologies. XOMA also has agreed to provide Affimed with cell line development and process development services specific to a TandAb therapeutic product candidate that Affimed is currently developing.

'Affimed's custom libraries represent a powerful addition to XOMA's existing collection of the seven leading commercial human antibody phage display libraries. The advantage of patient-derived libraries is their potential to contain unique antibody candidates for the therapeutic area of interest,' said Jack Castello, chairman of the board, president and chief executive officer of XOMA. 'This collaboration extends XOMA's leadership in therapeutic antibodies, providing a single point of access to an even broader fully-integrated antibody discovery and development platform.'

'We are delighted to enter into this broad cross-license and collaboration agreement with XOMA' said Rolf H. Günther MD PhD, chief executive officer of Affimed. 'The access to XOMA's state-of-the-art BCE technology represents another very important milestone for Affimed and provides new opportunities for the development of Affimed's promising recombinant antibody products. In addition to having the rights to use this technology in our development work, we are particularly pleased to have the benefit of XOMA's expertise in the development of cell lines and production systems for our TandAb therapeutic candidate.'

Further Information:
Paul Goodson
Sr. Director, Investor Relations
(510) 204-7270

Dr. Douglas Pretsell
Account Director, Munich Bureau Chief
Northbank Communications
t : +49 (0)89 57 00 18 06

About Affimed Therapeutics AG
Affimed is a private biopharmaceutical company based in Heidelberg, Germany and specializing in the development of recombinant antibodies - the fastest growing segment of the pharmaceutical industry. Affimed was founded in May of 2000 by Professor Melvyn Little as a spin-off of his group »Recombinant Antibodies« at the German Cancer Research Centre in Heidelberg.

The strength of Affimed's discovery platform lies in three large distinct antibody libraries that are the source of antibody leads which can be produced in a variety of formats from scFv, diabodies, full length antibodies to proprietary tetravalent formats such as Affimed's TandAb or Flexibody.

Affimed's existing pipeline comprises several very novel antibody formats targeting some potentially very high value cancer targets. Two cancer products are in advanced pre-clinical development. To learn more about Affimed, please visit

About XOMA and its Bacterial Cell Expression Technology
XOMA is a leader in the discovery, development and manufacture of therapeutic antibodies, with a therapeutic focus that includes cancer and immune diseases. XOMA has royalty interests in RAPTIVA® (efalizumab), a monoclonal antibody product marketed worldwide (by Genentech, Inc. and Serono, SA) to treat moderate-to-severe plaque psoriasis, and LUCENTIS(tm)<

Publisher Contact Information:

Affimed Therapeutics
+49 (0)89 57 00 18 06

Company profile of Affimed Therapeutics AG
Past press releases of Affimed Therapeutics AG.


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