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Affitech contracts with ProBioGen for producer cell line generation for oncology antibody candidate


Berlin and Oslo, April 11, 2007. - ProBioGen AG, and Affitech AS, jointly announced today that they have entered into an agreement for a biopharmaceutical cell line to be developed by ProBioGen for high-level production of one of the lead candidates in Affitech's oncology therapeutic antibody pipeline.

Under the terms of the agreement, ProBioGen will apply its proven cell generation process for biopharmaceutical cell lines relying on the unique vectors and its pre-optimized CHO starter cell. This will be combined with automated cloning process to identify and develop a high producer line, which should be particularly suitable for a fed-batch development process. Financial details of the agreement have not been disclosed.

'Our unique approach in developing high producer cell lines combined with our royalty free business model is very attractive to our customers and provides them with one of the crucial key features for a successful production process.' said Michael Schlenk, CEO at ProBioGen AG.

Announcing the agreement Dr. Martin Welschof, CEO of Affitech said: 'While several of our in-house discovered human antibodies are in various stages of preclinical development, in order to meet the demands of our ambitious development program for oncology antibody therapeutics, we have chosen a partner who offers us a high degree of flexibility and a compatible service-based development model.'


Note to editors:
ProBioGen AG is a specialist in cell line design, viral vectors, and manufacturing of glycoproteins for the biopharmaceutical industry. The German biotechnology company is headquartered in Berlin. Its range of products and services include the development of highly productive cell lines, the design of novel cell lines from primary tissue, the manufacture of glycoproteins for clinical studies and R&D, as well as the production of viral vectors and antibodies for in vitro diagnostics. ProBioGen possesses the manufacturing authorization for pharmaceutical active substances to be used in clinical studies and meets the quality standards recommended by the EU (EMEA) and the FDA. A certified cGMP multipurpose facility is available for contract manufacturing of biopharmaceutical active substances. The Company is specialized in mammalian cells and combines the know-how of molecular biology scientists with the experience of experts in cell culture technology and process engineering. ProBioGen thus accompanies its clients from the early development of product candidates up to late clinical testing phase.


Affitech AS is a privately held human therapeutic antibody discovery and development company with headquarters and R&D facilities in Oslo, Norway and its US subsidiary in the San Francisco Bay Area. The Company's current disease focus is oncology and it utilizes two discrete but unique approaches for the discovery of fully human antibodies - (i) Molecule Based Antibody Discovery, and (ii) Cell Based Antibody Discovery. Molecule Based Antibody Discovery involves proprietary PhagemidScreeN and AffiScreenN™ technologies and uses validated targets for discovery purpose. Cell Based Antibody Discovery is based on CBAS™ technology, which is a 'reverse-screening' approach for discovering antibodies and their cognate targets utilizing disease-specific cells. Several of the Company's proprietary product candidates currently in development were generated by CBAS™. Affitech also sells its proprietary Protein L product line for the purification of antibody and antibody fragments. Affitech offers collaborators a flexible business model and very competitive price structure with low royalty stacking. The Company has concluded deals with commercial organizations such as XOMA, NatImmune, Peregrine, Viventia, Dyax, and others. Further information at www.affitech.com.
xx


Publisher Contact Information:

Affitech AS
+47 22 95 88 77
m.welschof@affitech.com

Company profile of Affitech AS
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